2026-27 Webinar Series | October Session

ISIMM WEBINAR SERIES

Diagnostic, Prognostic, and Predictive IHC in Lung Neuroendocrine Neoplasia

October 21, 2026 | Webinar Recording

Featured Speaker
Natasha Rekhtman, MD, PhD

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Session Description

In this session, we will cover updates in immunohistochemistry (IHC) for lung neuroendocrine neoplasia, a field that has seen significant recent progress.

We will cover an update on diagnostic markers for lung carcinoids/NETs, including markers for site of origin (e.g., OTP), markers of emerging carcinoid/NET subtypes, as well as markers for various known and recently emerging mimickers of NETs that can present challenges in practice.

We will also cover diagnostic markers for neuroendocrine carcinomas, including POU2F3, and IHC for mimickers of NECs.

For prognostic markers, we will discuss the upcoming WHO update for lung carcinoid/NET grading, which will incorporate Ki67, and anticipated challenges.

Lastly, we will briefly discuss predictive markers, including DLL3.


Learning Objectives

Attendees will gain an updated understanding of the following applications of IHC in lung neuroendocrine neoplasia:

  1. Diagnosis
  2. Prognosis
  3. Theranosis

Target Audience

Pathologists, pathology residents and fellows, patient-facing clinicians, and scientists with an interest in neuroendocrine neoplasia.


Conflict of Interest Declaration

None to disclose.